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According to NICE guidance (NG28) , GLP-1 receptor agonists are recommended for adults with type 2 diabetes who have not achieved adequate glycaemic control with metformin and other oral agents, or as part of combination therapy in specific clinical circumstances

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The labelled peptides were analysed by nanoflow liquid chromatography-tandem mass spectrometry using an Easy-nLC system (Thermo) connected to a Q_Exactive HF-X (Thermo)